Towards electroenzymatic processes involving old yellow enzymes and mediated cofactor regeneration

A. Tosstorff, C. Kroner, D. J. Oppermann, F. Hollmann, D. Holtmann

Old yellow enzymes (OYEs) are able to catalyze asymmetric C = C reductions. A mediated electro enzymatic process to regenerate the NADPH in combination with an OYE was investigated. Due to the fact that the overall process was affected by a broad set of parameters a DoE approach was chosen to identify suitable process conditions. Process conditions with high productivities of up to 2.27 mM/h in combination with approx. 90% electron transfer efficiency were identified.

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