DSP - Purification of Biomolecules

16 - 19 October 2016

Design and Scale-Up by Laboratory Experiments and Process Simulation

In manufacturing of bio-molecules often 50-90 % of the Cost of Goods (COG) are caused by Downstream Processing (DSP). In process development separation processes must be proposed in an efficient sequence based on physico-chemical properties of target molecules, contaminants, side components and impurities to increase yield/recovery.

In this course the design of unit operations like ultrafiltration / diafiltration (UF/DF), ion exchange- and affinity-membranes as well as affinity, ion exchange (IEX), immobilized metal affinity (IMAC), size exclusion (SEC), hydrophobic interaction (HIC) and reversed phase chromatography is presented and explained. These are established key-technologies which are highly efficient and broadly used in manufacturing. Additionally, protein refolding, extraction and precipitation/crystallization are discussed. Moreover, methods for virus inactivation and clearance are explained.

Download of the flyer "DSP - Purification of Biomolecules"

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Your contact person

Nicola Gruß

Phone: +49 69 / 75 64-253

Heidi Weber-Heun

Phone: +49 69 / 75 64-202

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