Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

L. Getrey, T. Krieg, F. Hollmann, J. Schrader, D. Holtmann

The conversion of the phenolic monoterpenes thymol and carvacrol into antimicrobials by (electro)-chemoenzymatic halogenation was investigated using a chloroperoxidase (CPO) catalyzed process. The CPO catalysed process enables for the first time the biotechnological production of chlorothymol, chlorocarvacrol and bromothymol as well as a dichlorothymol with high conversion rates, total turnover numbers and space time yields of up to 90%, 164 000 and 4.6 mM h-1, respectively.−1

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